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The combination of dapagliflozin propanediol monohydrate and metformin hydrochloride tablets is a medication used in the treatment of type 2 diabetes mellitus. This combination offers the benefits of two different classes of antidiabetic medications, working synergistically to help manage blood glucose levels.

Dapagliflozin is an SGLT2 inhibitor that helps lower blood glucose levels by promoting the excretion of excess glucose through urine.

Metformin is a biguanide medication that primarily works by decreasing the liver’s production of glucose and improving the body’s sensitivity to insulin, helping to lower blood glucose levels.


  1. Type 2 Diabetes Management: The combination of dapagliflozin and metformin is prescribed to manage blood glucose levels in individuals with type 2 diabetes. It is typically used as part of a comprehensive treatment plan that includes a healthy diet, exercise, and other diabetes management strategies.
  2. Blood Glucose Control: Dapagliflozin and metformin work together to lower blood glucose levels through complementary mechanisms. Dapagliflozin promotes glucose excretion in urine, while metformin reduces the liver’s glucose production and improves insulin sensitivity.
  3. Cardiovascular Benefits: Some studies have suggested potential cardiovascular benefits associated with dapagliflozin, including a reduction in the risk of cardiovascular events. The combination might offer additional cardiovascular advantages.
  4. Weight Management: Dapagliflozin can lead to mild weight loss due to glucose excretion, which may be beneficial for individuals with type 2 diabetes who are overweight or obese.

Problems and Concerns:

  1. Genital Infections: Dapagliflozin can increase the risk of genital infections. Patients should maintain proper hygiene and seek medical attention if they experience symptoms like itching, redness, or discomfort.
  2. Urinary Tract Infections: There is a potential risk of urinary tract infections due to increased glucose excretion with dapagliflozin. Patients should stay hydrated and be aware of symptoms such as pain or burning during urination.
  3. Dehydration and Hypotension: Dapagliflozin can lead to increased urination and potential fluid loss. This may increase the risk of dehydration and hypotension, particularly in elderly patients or those taking diuretics.
  4. Lactic Acidosis (Metformin): Metformin has a rare but serious side effect called lactic acidosis. Patients with conditions that may increase the risk of lactic acidosis, such as kidney or liver dysfunction, should use metformin cautiously.
  5. Gastrointestinal Distress (Metformin): Some patients may experience gastrointestinal side effects, such as nausea, vomiting, or diarrhea, when taking metformin.
  6. Hypoglycemia: While dapagliflozin itself is not associated with hypoglycemia (low blood sugar), the risk of hypoglycemia might increase when combined with other diabetes medications like insulin or sulfonylureas.
  7. Kidney Function: Dapagliflozin and metformin may impact kidney function. Regular kidney function tests are recommended for patients using these medications.
  8. Individual Variability: Responses to medications can vary. Regular monitoring and communication with a healthcare provider are important.

Consultation with Healthcare Provider:

Individuals prescribed the combination of dapagliflozin propanediol monohydrate and metformin hydrochloride tablets should work closely with their healthcare provider. Regular monitoring of blood glucose levels, kidney function, and potential side effects is essential. This combination can be an effective tool in managing type 2 diabetes, but its use should be guided by a healthcare professional to ensure its safety and appropriateness for each individual’s health condition and needs.

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