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This combination medication contains two active ingredients: esomeprazole magnesium trihydrate and domperidone sustained-release (SR). It’s commonly prescribed to manage gastrointestinal conditions that involve excessive stomach acid production and gastrointestinal motility issues. Let’s explore its uses, potential benefits, and concerns.

Esomeprazole Magnesium Trihydrate:

  • Esomeprazole: It belongs to the class of medications called proton pump inhibitors (PPIs). Esomeprazole helps reduce stomach acid production by inhibiting the activity of proton pumps in the stomach lining.

Domperidone SR:

  • Domperidone: It is a medication that promotes gastrointestinal motility and is used to address issues related to delayed gastric emptying.
  • Sustained Release (SR): The sustained-release formulation of domperidone provides a gradual and extended release of the medication over time.


  1. Gastroesophageal Reflux Disease (GERD): The combination of esomeprazole and domperidone SR can be prescribed to manage GERD by reducing stomach acid production and promoting proper movement of stomach contents.
  2. Peptic Ulcers: This combination is used to treat peptic ulcers by reducing stomach acid and helping in ulcer healing.
  3. Gastroparesis: Gastroparesis is a condition characterized by delayed stomach emptying. Domperidone can help improve stomach motility, leading to better digestion and relief from symptoms.
  4. Nausea and Vomiting: Domperidone is commonly used to alleviate nausea and vomiting by enhancing the movement of food through the digestive tract.

Problems and Concerns:

  1. Long-Term Use of PPIs: Prolonged or excessive use of PPIs like esomeprazole may lead to an increased risk of certain health issues, including fractures, kidney disease, and Clostridium difficile infection.
  2. Rebound Acid Hypersecretion: After discontinuing PPIs, some individuals may experience a rebound effect where the stomach produces more acid than usual, potentially causing a temporary increase in symptoms.
  3. Nutritional Absorption: Long-term use of PPIs may interfere with the absorption of certain nutrients, such as calcium, magnesium, and vitamin B12.
  4. Domperidone and Cardiac Effects: Domperidone can have effects on heart rhythm, especially when used at higher doses or in certain populations. Regulatory agencies in some countries have issued warnings about its use.
  5. Interaction with Other Medications: Both esomeprazole and domperidone can interact with other medications, potentially affecting their effectiveness. Inform your healthcare provider about all medications you’re taking.
  6. Gastric Infections: While PPIs reduce stomach acid production, they may increase the risk of gastric infections in some individuals.
  7. Kidney Function: PPIs have been associated with a potential risk of acute kidney injury, particularly when used at higher doses or for extended periods.
  8. Bone Health: Long-term PPI use may be associated with a slightly increased risk of bone fractures, particularly in individuals with existing risk factors.
  9. Individual Response: Not everyone will experience the same effects or issues when taking this combination. Monitor your response and consult your healthcare provider if you have concerns.

Consultation with Healthcare Provider:

Before using esomeprazole magnesium trihydrate 40 mg and domperidone SR 30 mg, it’s important to consult a healthcare provider. They can evaluate your specific condition, discuss potential benefits and risks, and provide guidance on proper dosage and duration of use. Additionally, regular follow-up appointments can help monitor your response to the medication and address any concerns that may arise.

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